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Certara Appoints James E. Contact Investors Careers Support. Mon, November 25th Knowledge Base. Contact Us. PK parameters associated with steady state There are several special PK parameters associated with steady state kinetics. The situation is even simpler for intravenously administered drugs where you can directly calculate the C ss using the following equation: where R 0 is the rate of drug input.
The C ss is proportional to the infusion rate directly. Time to reach steady state The time to reach steady state is defined by the elimination half-life of the drug. Final thoughts Steady state pharmacokinetics are important for chronically administered drug products. About the author. Teuscher has been involved in clinical pharmacology and pharmacometrics work since He holds a PhD in Pharmaceutical Sciences from the University of Michigan and has held leadership roles at biotechnology companies, contract research organizations, and mid-sized pharmaceutical companies.
Prior to joining Certara, Dr. At Certara, Dr. Teuscher developed the software training department, led the software development of Phoenix, and now works as a pharmacometrics consultant. He specializes in developing fit-for-purpose models to support drug development efforts at all stages of clinical development.
He has worked in multiple therapeutic areas including immunology, oncology, metabolic disorders, neurology, pulmonary, and more. Teuscher is passionate about helping scientists leverage data to aid in establishing the safety and efficacy of therapeutics. Toggle Navigation. As repeated doses of a drug are administered its plasma concentration builds up and reaches what is known as a steady state.
This is when the amount of drug in the plasma has built up to a concentration level that is therapeutically effective and as long as regular doses are administered to balance the amount of drug being cleared the drug will continue to be active.
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